HTR1B Antibody
| Code | Size | Price |
|---|
| PSI-31-114-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store HTR1B antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
HTR1B, S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Application Note:
HTR1B antibody can be used for detection of HTR1B by ELISA at 1:12500. HTR1B antibody can be used for detection of HTR1B by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Background References:
- L, et al., (2004) Biol. Psychiatry 55 (3), 225-233.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HTR1B.
NCBI Gene ID #:
3351
NCBI Official Name:
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Official Symbol:
HTR1B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
NP_000854
Protein GI Number:
4504533
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Membrane ,Signal Transduction ,Immunology
Swissprot #:
P28222
User NOte:
Optimal dilutions for each application to be determined by the researcher.