Pyk2 Antibody
| Code | Size | Price |
|---|
| PSI-79-199-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK, MAPTL, MTBT1, TAU, FADK 2, Focal adhesion kinase 2, PTK2B, Proline-rich tyrosine kinase 2 RAFTK
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
Background References:
- Gluck SL, et al. (2004) J Clin Invest; 114 (12): 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98 (17): 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22 (8): 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21 (12): 4016-4031Krishnan HH, et al. (2006) J Virol; 80 (3): 1167-1180
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Pyk2 (Phospho-Tyr402) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y (p) -A-E) derived from Human Pyk2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2185
NCBI Official Name:
protein tyrosine kinase 2 beta
NCBI Official Symbol:
PTK2B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
116 kDa
Protein Accession #:
NP_004094.3
Protein GI Number:
27886584
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of Pyk2 only when phosphorylated at tyrosine 402.
Swissprot #:
Q14289