RBM5 Antibody
| Code | Size | Price |
|---|
| PSI-25-444-100ul | 100ul | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store RBM5 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
RBM5, FLJ39876, G15, H37, LUCA15, RMB5
Application Note:
RBM5 antibody can be used for detection of RBM5 by ELISA at 1:312500. RBM5 antibody can be used for detection of RBM5 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Background References:
- Oh, J.J., (2008) Hum. Genet. 123 (1), 55-64.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RBM5.
NCBI Gene ID #:
10181
NCBI Official Name:
RNA binding motif protein 5
NCBI Official Symbol:
RBM5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
Protein Accession #:
NP_005769
Protein GI Number:
5032031
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
RNA Binding ,Cell Cycle ,Cancer ,Apoptosis
Swissprot #:
P52756
User NOte:
Optimal dilutions for each application to be determined by the researcher.