BCL10 Monoclonal Antibody

Contact us
ProSci
Product Code: PSI-32-115
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-115-0.1mg0.1mg£524.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 4F8E8H8
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
BCL-10 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

1 / 2
Western blot analysis using BCL10 monoclonal antibody against truncated BCL10 recombinant protein and MCF - 7 cell lysate.
2 / 2
❮❯

Western blot analysis using BCL10 monoclonal antibody against truncated BCL10 recombinant protein and MCF - 7 cell lysate.

Documents

Further Information

Additional Names:
CIPER, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10, mE10, CIPER, c-E10, CARMEN
Application Note:
IHC(P):Dilution 1:1,000 - 1:2,000
IHC(F):Dilution 1:1,000 - 1:2,000
Western blot:Dilution 1:2,000 - 1:5,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-κB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Background References:
  • Willis, T.G., et al. (1999) Cell. 96, 35-45.
  • Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019.
  • Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
8915
NCBI Official Name:
B-cell CLL/lymphoma 10
NCBI Official Symbol:
BCL10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
O95999
Protein GI Number:
20454813
Purification:
Antibody is purified by protein A affinity chromatography.
Research Area:
Signal Transduction ,Apoptosis
Swissprot #:
O95999
User NOte:
Optimal dilutions for each application to be determined by the researcher.