KSHV ORF62 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-229-0.1mg | 0.1mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgM
Antibody Clonality: Monoclonal
Antibody Clone: 5B7B6
Regulatory Status: RUO
Target Species: Virus
Application: Western Blot (WB)
Storage:
to KSHV ORF62 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Triplex capsid protein VP19C homolog
Application Note:
Western Blot:1:500 - 1,000
ELISA:Determining optimal working dilutions by titration test.
ELISA:Determining optimal working dilutions by titration test.
Background:
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman?s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
Background References:
- Chang Y. et al. 1994. Science. 266:1865-1869.
- Russo J.J. et al. 1996. PNAS. 93: 14862-14867.
- Wu L. et al. 2000. J VirolOct; 74(20):9646-54.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
4961461
NCBI Official Name:
capsid triplex protein
NCBI Official Symbol:
ORF62
NCBI Organism:
Human herpesvirus 8
Protein Accession #:
F5H8Y5
Protein GI Number:
550600169
Research Area:
Infectious Disease
Swissprot #:
F5H8Y5
User NOte:
Optimal dilutions for each application to be determined by the researcher.