Fibulin 5 Monoclonal Antibody

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ProSci
Product Code: PSI-32-155
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-155-0.1mL0.1mL£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 3F10A5
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Fibulin 5 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Westernblot analysis using anti - human fibulin 5 monoclonal antibody agaist truncated Fibulin 5 recombinant protein and Hela lysate.
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Westernblot analysis using anti - human fibulin 5 monoclonal antibody agaist truncated Fibulin 5 recombinant protein and Hela lysate.

Documents

Further Information

Additional Names:
DANCE, UNQ184/PRO210, Developmental arteries and neural crest EGF-like protein, FIBL-5, EVEC, UP50, ADCL2, ARMD3, DANCE, ARCL1A
Application Note:
Western Blot:1:500 - 1:2000
IHC(P):1:500 - 1:2000
IHC(F):1:500 - 1:2000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
Fibulin 5(FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Background References:
  • Wen Wang , Scott A. LeMaire, Li Chen. Surgery. 2005 Aug;138(2):352-9
  • K. Kadoya, T. Sasaki, G. Kostka. Br J Dermatol. 2005 Sep;153(3):607-123.
  • Michael J. Lee, Nakshatra K. Roy, Jon E. Mogford. J Am Coll Surg. 2004 Sep;199(3):403-10.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant Fibulin 5 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
10516
NCBI Official Name:
fibulin 5
NCBI Official Symbol:
FBLN5
NCBI Organism:
Homo sapiens
Protein Accession #:
Q9UBX5
Protein GI Number:
12643876
Swissprot #:
Q9UBX5
User NOte:
Optimal dilutions for each application to be determined by the researcher.