PTK6 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-207-0.1mL | 0.1mL | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 2H12B8
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
PTK6 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
BRK, Breast tumor kinaseBRK
Application Note:
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Determining optimal working dilutions by titration test.
Background:
PTK6 (protein tyrosine kinase 6, BRK or FLJ42088),with 451-amino acid protein (about 51 kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.
Background References:
- Wilks, A.F. Proc. Natl. Acad. Sci. USA 86: 1603-1607.
- Ottilie, S., et al. Oncogene 7: 1625-1630.
- Lee, S.T., et al. Oncogene 8: 3403-3410.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant PTK6 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
5753
NCBI Official Name:
protein tyrosine kinase 6
NCBI Official Symbol:
PTK6
NCBI Organism:
Homo sapiens
Protein Accession #:
Q13882
Protein GI Number:
8928302
Research Area:
Signal Transduction
Swissprot #:
Q13882
User NOte:
Optimal dilutions for each application to be determined by the researcher.