Tyk2 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-232-0.1mL | 0.1mL | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 8G8E9?8G9H5
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Tyk2 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
JTK1
Application Note:
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-α, IFN-β, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
Background References:
- Michael H. Shaw, Gordon J. Freeman, Mark F. Scott. J. Immunol., Jun 2006; 176: 7263-7271.
- Yohei Seto, Hiroshi Nakajima, Akira Suto. J. Immunol., Jan 2003; 170: 1077.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
7297
NCBI Official Name:
tyrosine kinase 2
NCBI Official Symbol:
TYK2
NCBI Organism:
Homo sapiens
Protein Accession #:
P29597
Protein GI Number:
56405328
Research Area:
Signal Transduction
Swissprot #:
P29597
User NOte:
Optimal dilutions for each application to be determined by the researcher.