TYRO3 Monoclonal Antibody

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ProSci
Product Code: PSI-32-233
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-233-0.1mg0.1mg£560.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 1C10E8
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
TYRO3 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis using Tyro3 antibody against truncated Tyro3 recombinant protein.
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Western blot analysis using Tyro3 antibody against truncated Tyro3 recombinant protein.

Documents

Further Information

Additional Names:
BYK, DTK, RSE, SKY, TIF, Tyrosine-protein kinase BYKBYK, Dtk, Sky, Tif
Application Note:
Western Blot:1:500 - 1:2,000
IF:1:50 - 1:200
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
Tyrosine-protein kinase (TYRO3) belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
Background References:
  • Janssen, J.W.G., et al. 1991. Oncogene 6: 2113-2120.
  • Schlessinger, J., et al. 1992. Neuron 9: 383-391.
  • Biesecker, L.G., et al. 1995. Oncogene 10: 2239-2242.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant TYRO3 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
7301
NCBI Official Name:
TYRO3 protein tyrosine kinase
NCBI Official Symbol:
TYRO3
NCBI Organism:
Homo sapiens
Protein Accession #:
Q06418
Protein GI Number:
1717829
Research Area:
Signal Transduction ,Neuroscience
Swissprot #:
Q06418
User NOte:
Optimal dilutions for each application to be determined by the researcher.