TIAL1 Antibody
| Code | Size | Price |
|---|
| PSI-31-020-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Canine (dog)
- Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store TIAL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
TIAL1, TCBP, TIAR
Application Note:
TIAL1 antibody can be used for detection of TIAL1 by ELISA at 1:62500. TIAL1 antibody can be used for detection of TIAL1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly (A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain; however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.
Background References:
- Esclatine, A., et al., (2004) J. Virol. 78 (16), 8582-8592.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TIAL1.
NCBI Gene ID #:
7073
NCBI Official Name:
TIA1 cytotoxic granule-associated RNA binding protein-like 1
NCBI Official Symbol:
TIAL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
NP_003243
Protein GI Number:
4507499
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Transcription ,RNA Binding ,Cancer ,Apoptosis
Swissprot #:
Q01085
User NOte:
Optimal dilutions for each application to be determined by the researcher.