TNFRSF11B Antibody
| Code | Size | Price |
|---|
| PSI-31-004-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store TNFRSF11B antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
TNFRSF11B, OPG, TR1, OCIF
Application Note:
TNFRSF11B antibody can be used for detection of TNFRSF11B by ELISA at 1:312500. TNFRSF11B antibody can be used for detection of TNFRSF11B by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Background References:
- Cross, S.S., et al., (2006) Int. J. Cancer 118 (8), 1901-1908.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNFRSF11B.
NCBI Gene ID #:
4982
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 11b
NCBI Official Symbol:
TNFRSF11B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
NP_002537
Protein GI Number:
148743793
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Cancer ,Signal Transduction ,Apoptosis
Swissprot #:
O00300
User NOte:
Optimal dilutions for each application to be determined by the researcher.