MYST1 Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-197-0.1mL | 0.1mL | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 8C4C4
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
MYST1 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
MOF, MYST1, PP7073, Lysine acetyltransferase 8, MYST-1, MOF, hMOF, ZC2HC8
Application Note:
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
MYST1 (MYST histone acetyltransferase 1,MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone.
Background References:
- Sterner, D.E., et al. Microbiol. Mol. Biol 2000 Rev. 64: 435-459.
- Neal, K.C., et al. Biochim. Biophys. 2000 Acta 1490: 170-174.
- Akhtar, A., et al. EMBO 2001 Rep. 2: 113-118.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant MYST1-trx expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
84148
NCBI Official Name:
K(lysine) acetyltransferase 8
NCBI Official Symbol:
KAT8
NCBI Organism:
Homo sapiens
Protein Accession #:
Q9H7Z6
Protein GI Number:
68565938
Swissprot #:
Q9H7Z6
User NOte:
Optimal dilutions for each application to be determined by the researcher.