FER Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-32-151-0.1mL | 0.1mL | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 5D2C4
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
FER monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
TYK3, Feline encephalitis virus-related kinase FERFerT, TYK3, Pe1Fe3, Pe1Fe6, PPP1R74, Pe1Fe10, Pe1Fe13
Application Note:
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
Background References:
- Li L. Cheng X. Ling HQ. Plant Mol Biol. 2004, Jan, 54(1):125-36.
- Girault JA. Greengard P. Arch Neurol. 2004, May, 61(5):641-4.
- Fan L. Di Ciano-Oliveira C. Weed SA. et al. Biochem J. 2004, Jun 1, 380(Pt 2):581-91.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant FER-His expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
2241
NCBI Official Name:
fer (fps/fes related) tyrosine kinase
NCBI Official Symbol:
FER
NCBI Organism:
Homo sapiens
Protein Accession #:
P16591
Protein GI Number:
97536202
Research Area:
Signal Transduction
Swissprot #:
P16591
User NOte:
Optimal dilutions for each application to be determined by the researcher.