SNCA Monoclonal Antibody

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ProSci
Product Code: PSI-32-215
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-32-215-0.1mL0.1mL£560.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Clonality: Monoclonal
Antibody Clone: 2B2D1
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
SNCA monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis using SNCA monoclonal antibody against truncated SNCA recombinant protein.
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Western blot analysis using SNCA monoclonal antibody against truncated SNCA recombinant protein.

Documents

Further Information

Additional Names:
NACP, PARK1, Non-A beta component of AD amyloid, NACP, PD1, PARK4
Application Note:
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.
Background:
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Background References:
  • J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 ? 556.
  • Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13(4):385-90.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
6622
NCBI Official Name:
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Official Symbol:
SNCA
NCBI Organism:
Homo sapiens
Protein Accession #:
P37840
Protein GI Number:
586067
Research Area:
Neuroscience
Swissprot #:
P37840
User NOte:
Optimal dilutions for each application to be determined by the researcher.