ATM Antibody
| Code | Size | Price |
|---|
| PSI-79-156-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, APRF, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.
Background References:
- Gupta A. et al. (2005) Mol Cell Biol. 25 (12): 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4 (6): 249-252. Silverman J. et al. (2004) Genes Dev. 18 (17): 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31 (6): 1715-1724.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ATM (Phospho-Ser1981) antibody was raised against a peptide sequence around phosphorylation site of serine 1981 (E-G-S (p) -Q-S) derived from Human ATM.
Modifications:
Phospho-Specific
NCBI Gene ID #:
472
NCBI Official Name:
ataxia telangiectasia mutated
NCBI Official Symbol:
ATM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
350 kDa
Protein Accession #:
NP_000042.3
Protein GI Number:
71902540
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Apoptosis,Cancer,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of ATM only when phosphorylated at serine 1981.
Swissprot #:
Q13315