CREB Antibody

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ProSci
Product Code: PSI-79-293
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-293-0.1mg0.1mg£481.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 293, HT29 and HeLa cells using CREB (Ab-133).
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Ab-133).
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Western blot analysis of lysed extracts from 293, HT29 and HeLa cells using CREB (Ab-133).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Ab-133).

Documents

Further Information

Additional Names:
CREB, NR3C3, CREB-1, CREB1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Background References:
  • Xing J, et al. (1998) Mol Cell Biol 18 (4): 1946-55. Tan Y, et al. ( 1996) EMBO J; 15 (17): 4629-42. Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385. Mayo LD, et al. (2001) Biol Chem; 276 (27): 25184-9. Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-5934.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CREB (Ab-133) antibody was raised against a peptide sequence around aa. 131~135 (R-P-S-Y-R) derived from Human CREB.
NCBI Gene ID #:
1385
NCBI Official Name:
cAMP responsive element binding protein 1
NCBI Official Symbol:
CREB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
NP_004370.1
Protein GI Number:
4758054
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Apoptosis,Cancer,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of total CREB protein and it also detects the CREB-related protein ATF-1.
Swissprot #:
P16220