Amyloid Precursor Protein Antibody

Contact us
ProSci
Product Code: PSI-50-179
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-179-0.1mL0.1mL£686.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Canine (dog)
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Amyloid Precursor Protein antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

1 / 1
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.
❮❯

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.

Documents

Further Information

Application Note:
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).
Background References:
  • Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
  • Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37:925-937.
  • Liu F, Su Y, Li B, Zhou Y, Ryder J, Gonzalez-DeWhitt P, May PC, Ni B (2003) Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/cdk5 and p25/cdk5. FEBS Lett 547:193-196.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat APP.
NCBI Gene ID #:
54226
NCBI Official Name:
amyloid beta (A4) precursor protein
NCBI Official Symbol:
App
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
115
Protein Accession #:
P08592
Protein GI Number:
112930
Purification:
Affinity Purified
Swissprot #:
P08592
User NOte:
Optimal dilutions for each application to be determined by the researcher.