GRASP Antibody

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ProSci
Product Code: PSI-50-208
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-208-0.1mL0.1mL£686.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Canine (dog)
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
GRASP antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95k GRASP protein.
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Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95k GRASP protein.

Documents

Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).
Background References:
  • Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.
  • Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
116493
NCBI Official Name:
GRIP1 associated protein 1
NCBI Official Symbol:
Gripap1
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95
Protein Accession #:
Q9JHZ4
Protein GI Number:
76363169
Purification:
Affinity Purified
Swissprot #:
Q9JHZ4
User NOte:
Optimal dilutions for each application to be determined by the researcher.