PSD-95 Antibody

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ProSci
Product Code: PSI-50-169
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-169-0.1mL0.1mL£686.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Fish
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
PSD-95 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~95k PSD-95 protein.
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Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~95k PSD-95 protein.

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Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues. It is anticipated that the antibody will also work with bovine, human, mouse, non-human primates and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).
Background References:
  • Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.
  • Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
29495
NCBI Official Name:
discs, large homolog 4 (Drosophila)
NCBI Official Symbol:
Dlg4
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95
Protein Accession #:
P31016
Protein GI Number:
400891
Purification:
Affinity Purified
Swissprot #:
P31016
User NOte:
Optimal dilutions for each application to be determined by the researcher.