Rab 3 Antibody
| Code | Size | Price |
|---|
| PSI-50-187-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Amphibian
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Rab 3 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Background:
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has 4 known isoforms: 3A, 3B, 3C, and 3D (Schluter et al., 2004). These proteins are expressed in highest concentrations in brain and endocrine tissues and involved in regulated exocytosis of hormones and neurotransmitters (Coppola et al., 2002). Specifically, Rab3?s are thought to play a key role in presynaptic vesicle trafficking and priming (Schluter et al., 2006).
Background References:
- Schluter OM, Schmitz F, Jahn R, Rosenmund C, Sudhof TC (2004) A Complete Genetic Analysis of Neuronal Rab3 Function. J Neuroscience 24(29):6629-6637
- Schluter OM, Basu J, Sudhof TC, Rosenmund C (2006) Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-term Synaptic Plasticity. J Neuroscience 26(4):1239-1246
- Coppola T, Perret-Menoud V, Gattesco S, Magnin S, Pombo I, Blank U, Regazzi R (2002) The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. J Biochem 362 (Pt.2):273-9.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of rat Rab 3, conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
25531
NCBI Official Name:
RAB3A, member RAS oncogene family
NCBI Official Symbol:
Rab3a
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
27
Protein Accession #:
P63012
Protein GI Number:
51702793
Purification:
Affinity Purified
Swissprot #:
P63012
User NOte:
Optimal dilutions for each application to be determined by the researcher.