Vesicular GABA transporter Antibody

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ProSci
Product Code: PSI-50-194
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-194-0.1mL0.1mL£686.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Canine (dog)
  • Rat
Application: Western Blot (WB)
Storage:
Vesicular GABA transporter antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k VGAT protein.
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Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k VGAT protein.

Documents

Further Information

Background:
The Vesicular GABA Amino Acid Transporter (VGAT) is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles(McIntire et al., 1997). The VGAT protein (also known as the Vesicular Inhibitory Amino Aid Transporter or VIAAT) is expressed in synaptic vesicles of both glycine and GABAergic synapses throughout the CNS (Chaudhry et al., 1998). Expression of the VGAT protein changes during development and also in response to patterns of neuronal activity (De et al., 2005).
Background References:
  • Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, Storm-Mathisen J (1998) The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci 18:9733-9750.
  • De GS, Schafer MK, Defamie N, Chen C, Ricci A, Weihe E, Varoqui H, Erickson JD (2005) Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci 25:7121-7133.
  • McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM (1997) Identification and characterization of the vesicular GABA transporter. Nature (Lond ) 389:870-876.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of rat Vesicular GABA Amino Acid Transporter (VGAT).
NCBI Gene ID #:
83612
NCBI Official Name:
solute carrier family 32 (GABA vesicular transporter), member 1
NCBI Official Symbol:
Slc32a1
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53
Protein Accession #:
O35458
Protein GI Number:
29428082
Purification:
Affinity Purified
Swissprot #:
O35458
User NOte:
Optimal dilutions for each application to be determined by the researcher.