DOPA Decarboxylase Antibody

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ProSci
Product Code: PSI-50-202
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-202-0.1mL0.1mL£686.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Canine (dog)
  • Cavia (Guinea pig)
  • Human
  • Rabbit
  • Rat
  • Sheep
Application: Western Blot (WB)
Storage:
DOPA Decarboxylase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of 5 ug of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.
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Western blot of 5 ug of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.

Documents

Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots in bovine, canine, guinea pig, human, rabbit, rat and sheep tissues.
Background:
DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson?s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
Background References:
  • Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 21:1075-1087.
  • Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585.
  • Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide from N-terminus region of human DOPA decarboxylase (DDC), conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
1644
NCBI Official Name:
dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Official Symbol:
DDC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55
Protein Accession #:
P20711
Protein GI Number:
311033369
Purification:
Affinity Purified
Swissprot #:
P20711
User NOte:
Optimal dilutions for each application to be determined by the researcher.