Mouse anti T-Cell Receptor gamma delta
| Code | Size | Price |
|---|
| MUB1809P | 0.1 mg | £326.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 11F2
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Flow Cytometry
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
Storage:
Store at 4°C or in small aliquots at -20°C.
Documents
Further Information
Applications Description:
11F2 is useful for Enzyme Linked Immuno Sorbent Assays, Flow Cytometry, Immunohistochemistry on frozen sections and Immunoprecipitation. Optimal antibody dilution should be determined by titration.
Background:
Two types of T cell antigen receptors (TCRs) are now known, the ?/?, and the ?/? heterodimer, which are expressed at the cell surface in association with the CD3 molecular complex. TCR-? can occur in either disulphide-linked or non-disulphide-linked forms. The ?/? T-cell receptor is present on a minor subset of T lymphocytes in peripheral blood, thymus, spleen, and lymph node. In man and Mouse, only a small part of the T lymphocytes of the peripheral blood (<5%) is ?/?. ?/? T lymphocytes may complement ?/? T cells in terms of antigenic specificities, functional capabilities, or sites of action within the body.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.
This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.
This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Field of Interest:
Cell adhesion|Immunology
Formulation:
Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Product:
Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Source:
11F2 (anti-TCR gamma delta-l) is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells with spleen cells from a Balb/c mice immunized with protein A-Sepharose/anti-CD3/antigen complex.
Specificity:
Clone 11F2 recognizes all molecular forms of the gamma/delta T-cell receptor (TCR) desribed so far
References
1. Borst, J., Van Dongen, J., Bolhuis, R., Peters, P., Hafler, D., De Vries, E., Van de Griend, R. (1988). Distinct molecular forms of Human T cell receptor g/d detected on viable T cells by a monoclonal antibody. I. Exp. Med 167 1626-1644
2. Vroom, T., Scholte, G., Ossendorp, F., Borst, J. (1991). Tissue distribution of Human g/d T cells: No evidence for general epithelial tropism. J. Clon. Pathol. 44 1012-1017
3. Bos, J.D., Teunissen, M.B.M., Cairo, I., Krieg, S.R., Kapsenberg, M.L., Das, P.K., and Borst, J. (1990). T-cell receptor gamma delta bearing cells in normal Human skin J. Invest. Dermatol. 94: 37-42.
4. Lanier, L., Ruitenberg, J., Bolhuis, R., Borst, J., Phillips, J., Testi, R. (1988). Structural and serological heterogeneity of g/d T cell antigen receptor expression in thymus and peripheral blood. Eur J Immunol. 18 1985-1992
5. Lanier, L, Serafini, A., Ruitenberg, J., et all. (1987) The gamma T-cell antigen receptor. J Clin Immunol. 7 429 Testi, R., Lanier, L. (1989). Functional expression of CD28 on T cell antigen receptor g/d-bearing T lymphocytes. Eur J Immunol 19 185
6. Lanier, L., Federspiel, N., Ruitenberg, J., Phillips, J., Allison, J., Weiss, A. (1987(. The T cell antigen receptor complex expressed on normal peripheral blood CD4?-, CD8- T lymphocytes: A CD3-associated disulfide-linked g chain heterodimer. J Exp Med 165 1076-1094.
7. Voogt, P., Falkenburg, J., Fibbe, W., et al. (1989). Normal hematopoietic progenitor cells and malignant lymphohematopoietic cells show different susceptibility to direct cell-mediated MHC-non-restricted lysis by T cell receptor-/CD3-, T cell receptor gd+/CD3+ and T cell receptor-a/?+/CD3+ lymphocytes 142 1774-1780.
2. Vroom, T., Scholte, G., Ossendorp, F., Borst, J. (1991). Tissue distribution of Human g/d T cells: No evidence for general epithelial tropism. J. Clon. Pathol. 44 1012-1017
3. Bos, J.D., Teunissen, M.B.M., Cairo, I., Krieg, S.R., Kapsenberg, M.L., Das, P.K., and Borst, J. (1990). T-cell receptor gamma delta bearing cells in normal Human skin J. Invest. Dermatol. 94: 37-42.
4. Lanier, L., Ruitenberg, J., Bolhuis, R., Borst, J., Phillips, J., Testi, R. (1988). Structural and serological heterogeneity of g/d T cell antigen receptor expression in thymus and peripheral blood. Eur J Immunol. 18 1985-1992
5. Lanier, L, Serafini, A., Ruitenberg, J., et all. (1987) The gamma T-cell antigen receptor. J Clin Immunol. 7 429 Testi, R., Lanier, L. (1989). Functional expression of CD28 on T cell antigen receptor g/d-bearing T lymphocytes. Eur J Immunol 19 185
6. Lanier, L., Federspiel, N., Ruitenberg, J., Phillips, J., Allison, J., Weiss, A. (1987(. The T cell antigen receptor complex expressed on normal peripheral blood CD4?-, CD8- T lymphocytes: A CD3-associated disulfide-linked g chain heterodimer. J Exp Med 165 1076-1094.
7. Voogt, P., Falkenburg, J., Fibbe, W., et al. (1989). Normal hematopoietic progenitor cells and malignant lymphohematopoietic cells show different susceptibility to direct cell-mediated MHC-non-restricted lysis by T cell receptor-/CD3-, T cell receptor gd+/CD3+ and T cell receptor-a/?+/CD3+ lymphocytes 142 1774-1780.