22-NHC . HCl
| Code | Size | Price |
|---|
| AG-CR1-3523-M001 | 1 mg | £65.00 |
Quantity:
| AG-CR1-3523-M005 | 5 mg | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
22-Azacholesterol; (3beta)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
Appearance:
White solid.
CAS:
360068-87-7 or 3915-24-0 (free base)
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302, H319
InChi:
InChI=1S/C26H45NO.ClH/c1-17(2)12-15-27-18(3)22-8-9-23-21-7-6-19-16-20(28)10-13-25(19,4)24(21)11-14-26(22,23)5;/h6,17-18,20-24,27-28H,7-16H2,1-5H3;1H/t18?,20-,21-,22+,23-,24-,25-,26+;/m0./s1
InChiKey:
GDMMRLCQKPSXQG-USNJAYOWSA-N
Long Description:
Chemical. CAS: 360068-87-7 or 3915-24-0 (free base). Formula: C26H45NO . HCl. MW: 387.6 . 36.5. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .
MDL:
MFCD28898696
Molecular Formula:
C26H45NO . HCl
Molecular Weight:
387.6 . 36.5
Package Type:
Vial
Precautions:
P264, P270, P280, P301, P312
Product Description:
Aza-steroid [1]. Hedgehog signaling inhibitor [1]. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo) [1]. For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
[Cl-].[H][C@@]12CC[C@H]([C@H](C)[NH2+]CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9, 557 (2013)