Rubiginone A2
| Code | Size | Price |
|---|
| BVT-0023-M001 | 1 mg | £160.00 |
Quantity:
| BVT-0023-M005 | 5 mg | £610.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Fujianmycin B; SNA 8073A
Appearance:
Yellow solid.
CAS:
96695-58-8
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302
InChi:
InChI=1S/C20H16O5/c1-9-8-13(21)15-11(18(9)22)6-7-12-17(15)20(24)10-4-3-5-14(25-2)16(10)19(12)23/h3-7,9,18,22H,8H2,1-2H3/t9-,18+/m1/s1
InChiKey:
MUNUJAJWLPOQBH-LZVRBXCZSA-N
Long Description:
Chemical. CAS: 96695-58-8. Formula: C20H16O5. MW: 336.3. Isolated from Streptomyces sp. (strain Gö N1/5). Antibiotic. Antibacterial. Stereoisomer of SNA 8073B which is a prolyl endopeptidase (PEP) inhibitor. Vincristine-induced cytotoxicity potentiating activity against multi-drug-resistant tumor cells.
MDL:
MFCD00895766
Molecular Formula:
C20H16O5
Molecular Weight:
336.3
Package Type:
Plastic Vial
Precautions:
P264, P270, P301, P312
Product Description:
Antibiotic. Antibacterial. Stereoisomer of SNA 8073B which is a prolyl endopeptidase (PEP) inhibitor. Vincristine-induced cytotoxicity potentiating activity against multi-drug-resistant tumor cells.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
COC1=CC=CC2=C1C(=O)C1=C(C2=O)C2=C(C=C1)[C@@H](O)[C@H](C)CC2=O
Solubility Chemicals:
Soluble in DMSO or acetone; slightly soluble in methanol.
Source / Host:
Isolated from Streptomyces sp. (strain G? N1/5).
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark.
References
Fujianmycins A and B, new benz[a]anthraquinone antibiotics from a Streptomyces species: R.W. Rickards & J.P. Wu; J. Antibiot. 38, 513 (1985) | Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity: M. Oka, et al.; J. Antibiot. 43, 967 (1990) | SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. I. Fermentation, isolation and biological properties: K. Kimura, et al.; J. Antibiot. 50, 291 (1997) | Prolyl endopeptidase inhibitors derived from actinomycetes: K. Kimura, et al.; Biosci. Biotechnol. Biochem. 61, 1754 (1997) | New biologically active rubiginones from Streptomyces sp.: C. Puder, et al.; J. Antibiot. 53, 329 (2000)