XKR8 Antibody
| Code | Size | Price |
|---|
| PSI-7965-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7965-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 24431977
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
XKR8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8
Application Note:
XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a ?scramblase?, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).
Background References:
- Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.
- Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.
Buffer:
XKR8 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8.
The immunogen is located within the last 50 amino acids of XKR8.
The immunogen is located within the last 50 amino acids of XKR8.
NCBI Gene ID #:
55113
NCBI Official Name:
XK, Kell blood group complex subunit-related family, member 8
NCBI Official Symbol:
XKR8
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 43 kDa
Observed: 47 kDa
Observed: 47 kDa
Protein Accession #:
NP_060523
Protein GI Number:
24431977
Purification:
XKR8 antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Swissprot #:
Q9H6D3
User NOte:
Optimal dilutions for each application to be determined by the researcher.