PIK3C3 Antibody
| Code | Size | Price |
|---|
| PSI-7891-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7891-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 34761064
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
PIK3C3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
PIK3C3 Antibody: VPS34, hVps34, VPS34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, PI3-kinase type 3
Application Note:
PIK3C3 antibody can be used for detection of PIK3C3 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1). It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2). PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5).
Background References:
- Stopkova P, Saito T, Papolos DF, et al. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. Biol. Psychiatry 2004; 55:981-8.
- Hal BS, Gabernet-Castello C, Voak A, et al. TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J. Biol. Chem. 2006; 281:27600-12.
- Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem. J. 2008; 410:1-17.
- Jaber N, Dou Z, Lin RZ, et al. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 2012; 8:707-8.
Buffer:
PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%)
Immunogen:
PIK3C3 antibody was raised against an 18 amino acid peptide near the amino terminus of human PIK3C3.
The immunogen is located within amino acids 130 - 180 of PIK3C3.
The immunogen is located within amino acids 130 - 180 of PIK3C3.
NCBI Gene ID #:
5289
NCBI Official Name:
phosphatidylinositol 3-kinase, catalytic subunit type 3
NCBI Official Symbol:
PIK3C3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 91, 98 kDa
Observed: 98 kDa
Observed: 98 kDa
Protein Accession #:
NP_002638
Protein GI Number:
34761064
Purification:
PIK3C3 antibody is affinity chromatography purified via peptide column.
Research Area:
Autophagy
SPECIFICITY:
PIK3C3 antibody is human, mouse and rat reactive.
Swissprot #:
Q8NEB9
User NOte:
Optimal dilutions for each application to be determined by the researcher.