TICRR Antibody

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ProSci
Product Code: PSI-7857
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-7857-0.02mg0.02mg£150.00
Quantity:
PSI-7857-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 118421085
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
TICRR antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Images

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Western blot analysis of TICRR in human small intestine tissue lysate with TICRR antibody at 1 μg/ml.
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Immunohistochemistry of TICRR in human small intestine tissue with TICRR antibody at 5 μg/mL.
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Immunofluorescence of TICRR in human small intestine tissue with TICRR antibody at 20 μg/mL.
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Western blot analysis of TICRR in human small intestine tissue lysate with TICRR antibody at 1 μg/ml.
Immunohistochemistry of TICRR in human small intestine tissue with TICRR antibody at 5 μg/mL.
Immunofluorescence of TICRR in human small intestine tissue with TICRR antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
TICRR Antibody: SLD3, Treslin, C15orf42, TopBP1-interacting checkpoint and replication regulator
Application Note:
TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42
Background References:
  • Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.
  • Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.
  • Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.
  • Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.
Buffer:
TICRR antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (74%)
Immunogen:
TICRR antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TICRR.

The immunogen is located within amino acids 1840 - 1890 of TICRR.
NCBI Gene ID #:
90381
NCBI Official Name:
TOPBP1-interacting checkpoint and replication regulator
NCBI Official Symbol:
TICRR
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 210 kDa

Observed: 220 kDa
Protein Accession #:
NP_689472
Protein GI Number:
118421085
Purification:
TICRR antibody is affinity chromatography purified via peptide column.
Research Area:
Cell Cycle
SPECIFICITY:
TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.
Swissprot #:
Q7Z2Z1
User NOte:
Optimal dilutions for each application to be determined by the researcher.