ANGPTL3 Antibody
| Code | Size | Price |
|---|
| PSI-7865-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7865-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 7656888
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
ANGPTL3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
ANGPTL3 Antibody: ANL3, ANG-5, FHBL2, ANGPT5, UNQ153/PRO179, Angiopoietin-related protein 3, Angiopoietin-5
Application Note:
ANGPTL3 antibody can be used for detection of ANGPTL3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
The angiopoietin-related protein 3 (ANGPTL3) is a member of a family of secreted proteins that function in angiogenesis (1). ANGPTL3 is processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis (2,3). Recent experiments have shown that a deficiency of ANGPTL3 is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids, suggesting that ANGPTL3 may also play a role in modulating glucose metabolism (4).
Background References:
- Conklin D, Gilbertson D, Taft DW, et al. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 1999; 62:477-82.
- Koishi R, Ando Y, Ono M, et al. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 2002; 30:151-7.
- Camenisch G, Pisabarro MT, Sherman D, et al. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.J. Biol. Chem. 2002; 277:17281-90.
- Robciuc MR, Maranghi M, Lahikainen A, et al. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arterioscler. Thromb. Vasc. Biol. 2013; 33:1706-13.
Buffer:
ANGPTL3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ANGPTL3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ANGPTL3.
The immunogen is located within the last 50 amino acids of ANGPTL3.
The immunogen is located within the last 50 amino acids of ANGPTL3.
NCBI Gene ID #:
27329
NCBI Official Name:
angiopoietin-like 3
NCBI Official Symbol:
ANGPTL3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 51 kDa
Observed: 53 kDa
Observed: 53 kDa
Protein Accession #:
NP_055310
Protein GI Number:
7656888
Purification:
ANGPTL3 antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis,Obesity
SPECIFICITY:
ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.
Swissprot #:
Q9Y5C1
User NOte:
Optimal dilutions for each application to be determined by the researcher.