DCNP1 Antibody
| Code | Size | Price |
|---|
| PSI-7769-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7769-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 18677770
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
DCNP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
DCNP1 Antibody: DCNP1, C5orf20, Dendritic cell nuclear protein 1
Application Note:
DCNP1 antibody can be used for detection of DCNP1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1). It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3). DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4).
Background References:
- Masuda M, Senju S, Fujii Si S, et al. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. Biochem. Biophys. Res. Commun. 2002; 290:1022-9.
- Willis-Owen SA, Shifman S, Copley RR, et al. DCNP1: a novel candidate gene for major depression. Mol. Psychiatry 2006; 11:121-2.
- Bosker FJ, Hartman CA, Nolte IM, et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol. Psychiatry 2011; 16:516-32.
- Zhou T, Wang S, Ren H, et al. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010; 133:3069-79.
Buffer:
DCNP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DCNP1 antibody was raised against an 18 amino acid peptide near the amino terminus of human DCNP1.
The immunogen is located within the first 50 amino acids of DCNP1.
The immunogen is located within the first 50 amino acids of DCNP1.
NCBI Gene ID #:
140947
NCBI Official Name:
chromosome 5 open reading frame 20
NCBI Official Symbol:
C5orf20
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 27 kDa
Observed: 24 kDa
Observed: 24 kDa
Protein Accession #:
NP_570900
Protein GI Number:
18677770
Purification:
DCNP1 antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
DCNP1 antibody is human, mouse and rat reactive.
Swissprot #:
Q8TF63
User NOte:
Optimal dilutions for each application to be determined by the researcher.