KCNK1 Antibody
| Code | Size | Price |
|---|
| PSI-8017-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8017-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 4504847
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
KCNK1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
Potassium channel subfamily K member 1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1
Application Note:
KCNK1 antibody can be used for detection of KCNK1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2). KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1). Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3).
Background References:
- Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996; 15:1004-11.
- Goldstein SA, Bockenhauer D, O'Kelly I, et al. Potassium leak channels and the KCNK family of two-P domain subunits. Nat. Rev. Neurosci. 2001; 2:175-84.
- Zhou M, Xu G, Xie M, et al. TWIK-1 and TREK-2 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slides. J. Neurosci. 2009; 29:8551-64.
Buffer:
KCNK1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Guinea pig: (100%)
Immunogen:
KCNK1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KCNK1.
The immunogen is located within amino acids 220 - 270 of KCNK1.
The immunogen is located within amino acids 220 - 270 of KCNK1.
NCBI Gene ID #:
3775
NCBI Official Name:
potassium channel, subfamily K, member 1
NCBI Official Symbol:
KCNK1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 37 kDa
Observed: 35 kDa
Observed: 35 kDa
Protein Accession #:
NP_002236
Protein GI Number:
4504847
Purification:
KCNK1 antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
KCNK1 antibody is human, mouse and rat reactive. KCNK1 antibody is predicted to not cross-react with other KCNK proteins.
Swissprot #:
O00180
User NOte:
Optimal dilutions for each application to be determined by the researcher.