SNCA Antibody
| Code | Size | Price |
|---|
| PSI-7911-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7911-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Antibody Clone: 6806898
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SNCA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Documents
Further Information
Additional Names:
SNCA Antibody: PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid
Application Note:
SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
Alpha-Synuclein (SNCA) is a hallmark of Alzheimer?s disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson?s disease (4,5).
Background References:
- Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.
- Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.
- Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.
- Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.
Buffer:
SNCA antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)
Immunogen:
SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA.
The immunogen is located within the last 50 amino acids of SNCA.
The immunogen is located within the last 50 amino acids of SNCA.
NCBI Gene ID #:
6622
NCBI Official Name:
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Official Symbol:
SNCA
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 12 kDa
Observed: 16 kDa
Observed: 16 kDa
Protein Accession #:
NP_000336
Protein GI Number:
6806898
Purification:
SNCA antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience,Apoptosis
SPECIFICITY:
SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.
Swissprot #:
P37840
User NOte:
Optimal dilutions for each application to be determined by the researcher.