Jagged-2 (human):Fc (human) (rec.)

Protein Jagged-2; hJ2; JAG2

0.1mg/ml after reconstitution

32160000

<0.1EU/µg purified protein (LAL test; Lonza).

solid

Lyophilized. Contains PBS + 0.02 % CHAPS.

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.

Protein. Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. Source: HEK 293 cells. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.02 % CHAPS. Purity: >90% (SDS-PAGE). Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

~150kDa (SDS-PAGE)

Q9Y219

Plastic Vial

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

>90% (SDS-PAGE)

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

HEK 293 cells

Fc

Non-hazardous

Other Proteins

12352202

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.