BQ-788 . sodium salt
| Code | Size | Price |
|---|
| AG-CP3-0012-C500 | 500 ug | £173.00 |
Quantity:
| AG-CP3-0012-M001 | 1 mg | £217.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
ETB Receptor Antagonist; N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine
Appearance:
White to off-white solid.
CAS:
156161-89-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1
InChiKey:
QCVIFBRTTLMEOV-FUKQNADPSA-M
Long Description:
Chemical. CAS: 156161-89-6. Formula: C34H50N5O7 . Na. MW: 640.8 . 23.0. Synthetic. Potent and selective endothelin B receptor (ETBR) antagonist.
MDL:
MFCD00797882
Molecular Formula:
C34H50N5O7 . Na
Molecular Weight:
640.8 . 23.0
Package Type:
Vial
Product Description:
Potent and selective endothelin B receptor (ETBR) antagonist.
Purity:
>95% (HPLC)
SMILES:
CCCC[C@@H](NC(=O)[C@@H](CC1=CN(C(=O)OC)C2=C1C=CC=C2)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O[Na]
Solubility Chemicals:
Soluble in DMSO, 0.1M sodium bicarbonate or 100% ethanol. Slightly soluble in methanol. Insoluble in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Clearance of circulating endothelin-1 by ETB receptors in rats: T. Fukuroda, et al.; BBRC 199, 1461 (1994) | Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788: K. Ishikawa, et al.; PNAS 91, 4892 (1994) | Novel antagonist of endothelin ETB1 and ETB2 receptors, BQ-788: effects on blood vessel and small intestine: H. Karaki, et al.; BBRC 205, 168 (1994) | PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat: R.L. Schroeder, et al.; J. Cardiovasc. Pharmacol. 32, 935 (1998) | BQ-788, a selective endothelin ETB receptor antagonist: M. Okada & M. Nishikibe; Cardiovasc. Drug Rev. 20, 53 (2002)
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