Triptolide

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AdipoGen Life Sciences
Product Code: AG-CN2-0448
CodeSizePrice
AG-CN2-0448-M0011 mg£32.00
Quantity:
AG-CN2-0448-M0055 mg£75.00
Quantity:
AG-CN2-0448-M01010 mg£120.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C

Images

1 / 1
Chemical Structure
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Chemical Structure

Documents

Further Information

Alternate Names/Synonyms:
PG 490; NSC163062
Appearance:
Crystalline solid.
CAS:
38748-32-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Keep under inert gas.Protect from light.
InChi:
InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChiKey:
DFBIRQPKNDILPW-KTGKZQHOSA-N
Long Description:
Chemical. CAS: 38748-32-2. Formula: C20H24O6. MW: 360.4. Isolated from Tripterygium sp. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects.
MDL:
MFCD00210565
Molecular Formula:
C20H24O6
Molecular Weight:
360.4
Package Type:
Vial
Product Description:
Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects.
Purity:
>98% (HPLC)
SMILES:
CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3CC3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
Solubility Chemicals:
Soluble in DMSO. Sparingly soluble in ethanol.
Source / Host:
Isolated from Tripterygium sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii: S.M. Kupchan, et al.; JACS 94, 7194 (1972) | Triptolide: a potential male contraceptive: Y. Lue, et al.; J. Androl. 19, 479 (1998) | Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998) | Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes: H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000) | Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F: B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review) | Triptolide inhibits the growth and metastasis of solid tumors: S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003) | Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006) | Triptolide alters mitochondrial functions: Y. Su, et al.; Adv. Exp. Med. Biol. 599, 139 (2007) | Triptolide functions as a potent angiogenesis inhibitor: M.F. He, et al.; Int. J. Cancer 126, 266 (2010) | Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors: S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011) | RNA polymerase - an important molecular target of triptolide in cancer cells: J. Pan; Cancer Lett. 292, 149 (2010) (Review) | Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways: N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010) | Triptolide and its expanding multiple pharmacological functions: Q. Liu; Int. Immunopharmacol. 11, 377 (2011) (Review) | XPB, a subunit of TFIIH, is a target of the natural product triptolide: D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011) | Triptolide directly inhibits dCTP pyrophosphatase: T.W. Corson, et al.; Chembiochem 12, 1767 (2011) | Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II): Y. Wang, et al.; PLoS One 6, e23993 (2011) | Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms: Z.L. Zhou, et al.; Nat. Prod. Rep. 29, 457 (2012) | Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells: J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011) | TAB1: a target of triptolide in macrophages: Y. Lu, et al.; Chem. Biol. 21, 246 (2014) | Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/beta-catenin signaling pathway: H. Shao, et al.; Exp. Ther. Med. 8, 505 (2014) | Triptolide Induces Cell Damage in Lipopolysaccharide (LPS)-Treated Macrophages in an LPS-Signaling Cascade-Dependent Manner: K. Kohama, et al.; J. Cytokine Biol. 2, (2017)

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