Ganglioside GM2 . sodium salt (bovine brain)

GM2 . Na; Monosialoganglioside GM2 . Na

19600-01-2

32160000

Not detectable.

solid

Lyophilized.

Hygroscopic.Protect from moisture.

InChI=1S/C67H121N3O26.Na/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-50(80)70-43(44(77)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-89-64-57(85)56(84)59(48(38-73)91-64)93-65-58(86)62(60(49(39-74)92-65)94-63-52(69-42(4)76)55(83)54(82)47(37-72)90-63)96-67(66(87)88)35-45(78)51(68-41(3)75)61(95-67)53(81)46(79)36-71;/h31,33,43-49,51-65,71-74,77-79,81-86H,5-30,32,34-40H2,1-4H3,(H,68,75)(H,69,76)(H,70,80)(H,87,88);/q;+1/p-1/b33-31+;/t43-,44+,45?,46+,47?,48?,49?,51+,52?,53-,54-,55?,56?,57?,58?,59+,60-,61?,62?,63+,64+,65-,67-;/m0./s1

YZCIBJIDUSQSAE-AGTWZOCMSA-M

Chemical. CAS: 19600-01-2. Formula: C67H120N3O26 . Na. MW: 1383.7 . 23.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM2 is a very minor component of the nervous system, but it is accumulated in brains from Tay-Sachs and Sandhoff disease patients, due to genetic defect of lysosomal beta-hexosaminidase.

MFCD00131137

C67H120N3O26 . Na

1383.7 . 23.0 (calculated on sphingosine C18:1 and stearic acid)

Glass Vial

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM2 is a very minor component of the nervous system, but it is accumulated in brains from Tay-Sachs and Sandhoff disease patients, due to genetic defect of lysosomal beta-hexosaminidase.

>98% (TLC)

Structure: II3Neu5AcGgOse3Cer; beta-GalNAc-(1-4)-[alpha-Neu5Ac-(2-3)-]beta-Gal-(1-4)-beta-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90%

[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@H]1C(O)[C@H](O[C@H]2C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)C=CCCCCCCCCCCCCC)O[C@H]2CO)OC(CO)[C@@H]1O[C@H]1O[C@@H](CO)[C@H](O)C(O)C1NC(C)=O)C([O-])=O

Soluble in water (liposomal aggregates) or chloroform:methanol (2:1).

Isolated from bovine brain.

Non-hazardous

Glycolipids/Phospholipids/Sphingolipids

12352211

Stable for at least 2 years after receipt when stored at -20°C.