(S)-(+)-Naproxene

Naprosyn; Equiproxen; Laraflex; (S)-(+)-6-Methoxy-alpha-methyl-2-naphthalene acetic acid

White powder.

22204-53-1

6.1a

32160000

liquid

GHS06

Keep cool and dry.Protect from light and moisture.

H301

InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

CMWTZPSULFXXJA-UHFFFAOYSA-N

Chemical. CAS: 22204-53-1. Formula: C14H14O3. MW: 230.26. Synthetic Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Abeta fibril growth and form a complex with copper (II).

MFCD00010500

C14H14O3

230.26

Vial

III

P264, P270, P301, P310, P321, P330, P405, P501

Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Abeta fibril growth and form a complex with copper (II).

>98% (HPLC)

Danger

COC1=CC=C2C=C(C=CC2=C1)[C@H](C)C(O)=O

Soluble in water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate or tetrahydrofuran.

Synthetic

Excepted Quantity

UN 3249

Biochemical Reagents

12352200

Stable for at least 2 years after receipt when stored at +4°C.