DETA NONOate
| Code | Size | Price |
|---|
| AG-CR1-3614-M005 | 5 mg | £54.00 |
Quantity:
| AG-CR1-3614-M025 | 25 mg | £117.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-80°C
Storage:
-80°C
Documents
Further Information
Alternate Names/Synonyms:
DETA/NO; Diethylenetriamine NONOate; NOC-18; 2,2'-(Hydroxynitrosohydrazono)bis-ethanamine
Appearance:
White to off-white solid.
CAS:
146724-94-9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep under inert gas.Protect from moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
InChiKey:
PAOXTYJXTPPVHU-UHFFFAOYSA-O
Long Description:
Chemical. CAS: 146724-94-9. Formula: C4H13N5O2. MW: 163.2. Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
MDL:
MFCD00210194
Molecular Formula:
C4H13N5O2
Molecular Weight:
163.2
Other data:
UV absorbance: 252nm (epsilon = 7.640M-1cm-1)
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Purity:
>98%
Signal word:
Warning
SMILES:
NCCN(CC[NH3+])N([O-])N=O
Solubility Chemicals:
Soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Nitric Oxide Donors
UNSPSC Number:
41116113
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.
References
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993) | Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators: L.K. Keefer & D. Morley; J. Cardiovasc. Pharmacol. 22, 3 (1993) | Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats: S. Shibuta, et al.; Neurosci. Lett. 187, 103 (1995) | NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995) | Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro: D.L. Mooradian, et al.; J. Cardiovasc. Pharmacol. 25, 674 (1995) | NONOates (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms: L.K. Keefer, et al.; Methods Enzymol. 268, 281 (1996) | The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006) | In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF: S. Huerta, et al.; Nitric Oxide 20, 182 (2009) | Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC: O. Arandarcikaite, et al.; Neurosci. Lett. 586, 65 (2015)
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