Bloom Syndrome (phospho Ser186) Antibody

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ProSci
Product Code: PSI-39-857
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-39-857-0.05mg0.05mg£782.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Non-Human Primates
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Documents

Further Information

Additional Names:
Bloom Syndrome Protein pS186 phospho specific, BS, RECQ2, RECQL2, RECQL3
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Background:
The Bloom syndrome gene product is a member of the RecQ helicase protein family. The protein contains 1417 amino acids; including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. BLS protein is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. The Bloom's syndrome gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes.
Background References:
  • Nathan A. Ellis, Joanna Groden,,Tian-Zhang Ye, Joel Straughen, David J. Lennon, Susan Ciocci , Maria Proytcheva and James German The Bloom's syndrome gene product is homologous to RecQ helicases. Cell, (1994) Vol. 83, 655-668
  • Davies SL, North PS, Dart A, Lakin ND, Hickson ID.,Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol. (2004) Feb;24(3):1279-91
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
A synthetic peptide surrounding amino acid S186.
Modifications:
Phospho-Specific
NCBI Gene ID #:
641
NCBI Official Name:
Bloom syndrome, RecQ helicase-like
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAI15031
Protein GI Number:
1705486
Purification:
Affinity Purified
Research Area:
Phospho-Specific
Swissprot #:
P54132
User NOte:
Optimal dilutions for each application to be determined by the researcher.