Tropomyosin-1a (Ser 283) Antibody

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ProSci
Product Code: PSI-39-877
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-39-877-0.05mg0.05mg£765.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Chicken (Gallus)
  • Human
  • Mouse
  • Non-Human Primates
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Documents

Further Information

Additional Names:
Tropomyosin-1 (alpha), phospho serine 283, CMH3, TMSA, CMD1Y, LVNC9, C15orf13, HTM-alpha
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Background:
Tropomyosin (Tpm-1)consists of a family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction..
Background References:
  • Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat. Yuan, C., Sheng, Q., Tang, H.,Tixue, L., Zeng, R., and Solaro, R.J.. Am J Physiol Heart Circ Physiol.2008; 295: H647-H656.
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ. Circ Res. 2007 Feb 16;100(3):408-15.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
A synthetic phosphopeptide corresponding to the region surrounding S283.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7168
NCBI Official Name:
tropomyosin 1 (alpha)
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
AAT68294
Protein GI Number:
136092
Purification:
Affinity Purified
Research Area:
Phospho-Specific
Swissprot #:
P09493
User NOte:
Optimal dilutions for each application to be determined by the researcher.