SLC29A2 Antibody
| Code | Size | Price |
|---|
| PSI-8127-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8127-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SLC29A2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
Solute carrier family 29 member 2, Equilibrative nucleoside transporter 2, ENT2, DER12, HNP36
Application Note:
SLC29A2 antibody can be used for detection of SLC29A2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SLC29A2 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2). SLC29A2 is a transmembrane glycoprotein that mediates the cellular uptake of nucleosides from the surrounding medium (3). As a nucleoside transporter, SLC29A2 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4).
Background References:
- Williams JB and Lanahan AA. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. Biochim. Biophys. Res. Commun. 1995; 213:325-33.
- Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.
- Mangravite LM, Xiao G, and Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am. J. Physiol. Renal Physiol. 284:F902-10.
- Owen RP, Lagpacan LL, Taylor TR, et al. Functional characterization and haplotype analysis of polymorphisms in the human equilabrative nucleoside transporter, ENT2. Drug Metab. Dispos. 2006; 34:12-5.
Buffer:
SLC29A2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Immunogen:
SLC29A2 antibody was raised against a 19 amino acid peptide near the center of human SLC29A2.
The immunogen is located within amino acids 250 - 300 of SLC29A2.
The immunogen is located within amino acids 250 - 300 of SLC29A2.
NCBI Gene ID #:
3177
NCBI Official Name:
solute carrier family 29 (equilibrative nucleoside transporter), member 2
NCBI Official Symbol:
SLC29A2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 50 kDa
Observed: 50 kDa
Observed: 50 kDa
Protein Accession #:
NP_001523
Protein GI Number:
38708299
Purification:
SLC29A2 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Homeostasis
SPECIFICITY:
SLC29A2 antibody is human specific. SLC29A2 antibody is predicted to not cross-react with other SLC29 proteins.
Swissprot #:
Q14542
User NOte:
Optimal dilutions for each application to be determined by the researcher.