SLCO1B1 Antibody
| Code | Size | Price |
|---|
| PSI-8197-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8197-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SLCO1B1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
Solute carrier organic anion transporter family member 1B1, LST1, Solute carrier family 21 member 6, SLC21A6, Sodium-independent organic anion-transporting polypeptide 2, OATP1B1, OATP2, OATPC, Solute carrier family 21 member 6
Application Note:
SLCO1B1 antibody can be used for detection of SLCO1B1 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2). It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3). SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4).
Background References:
- Abe T, Kakyo M, Tokui T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 1999; 274:17159-63.
- Konig J, Cui Y, Nies AT, et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 278:G156-64.
- Michalski C, Cui Y, Nies AT, et al. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J. Biol. Chem. 2002; 277:43058-63.
- Yao J, Hong W, Huang J, et al. N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One 2012; 7:e52563.
Buffer:
SLCO1B1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SLCO1B1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human SLCO1B1.
The immunogen is located within the last 50 amino acids of SLCO1B1.
The immunogen is located within the last 50 amino acids of SLCO1B1.
NCBI Gene ID #:
10599
NCBI Official Name:
solute carrier organic anion transporter family, member 1B1
NCBI Official Symbol:
SLCO1B1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 76 kDa
Observed: 75 kDa
Observed: 75 kDa
Protein Accession #:
NP_006437
Protein GI Number:
225543525
Purification:
SLCO1B1 antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.
Swissprot #:
Q9Y6L6
User NOte:
Optimal dilutions for each application to be determined by the researcher.