CDO1 Antibody

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ProSci
Product Code: PSI-8137
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-8137-0.02mg0.02mg£150.00
Quantity:
PSI-8137-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
CDO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Images

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Western blot analysis of CDO1 in rat liver tissue lysate with CDO1 antibody at (A) 1 and (B) 2 μg/ml.
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Western blot analysis of CDO1 in rat liver tissue lysate with CDO1 antibody at (A) 1 and (B) 2 μg/ml.

Documents

Further Information

Additional Names:
Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1
Application Note:
CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1). CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1,2). CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1). CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3,4).
Background References:
  • McCann KP, Akbari MT, Williams AC, et al. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. Biochim. Biophys. Acta 1994; 1209:107-10.
  • Ye S, Wu X, Wei L, et al. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J. Biol. Chem. 2007; 282:3391-402.
  • Booken N, Gratchev A, Utikal J, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia 2008; 22:393-9.
  • Wrangle J, Machida EO, Danilova L, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin. Cancer Res. 2014; 20:1856-64.
Buffer:
CDO1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (84%)
Immunogen:
CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1.

The immunogen is located within amino acids 30 - 80 of CDO1.
NCBI Gene ID #:
1036
NCBI Official Name:
Cysteine dioxygenase type 1
NCBI Official Symbol:
CDO1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 22 kDa

Observed: 24 kDa
Protein Accession #:
NP_001792
Protein GI Number:
56786147
Purification:
CDO1 antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
CDO1 antibody is human, mouse and rat reactive.
Swissprot #:
Q16878
User NOte:
Optimal dilutions for each application to be determined by the researcher.