FOXG1 Antibody

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ProSci
Product Code: PSI-8089
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-8089-0.02mg0.02mg£150.00
Quantity:
PSI-8089-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
FOXG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Images

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Western blot analysis of FOXG1 in rat brain tissue lysate with FOXG1 antibody at 1 μg/ml.
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Immunofluorescence of FOXG1 in mouse brain tissue with FOXG1 antibody at 20 μg/ml.
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Western blot analysis of FOXG1 in rat brain tissue lysate with FOXG1 antibody at 1 μg/ml.
Immunofluorescence of FOXG1 in mouse brain tissue with FOXG1 antibody at 20 μg/ml.

Documents

Further Information

Additional Names:
Forkhead box G1, Brain factor 1, Brain factor 2, BF1, BF2, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, Forkhead box protein G1, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
Application Note:
FOXG1 antibody can be used for detection of FOXG1 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
FOXG1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain and plays an important role in the development of the brain and telencephalon (1). It is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (2,3). Expression is restricted to the neurons of the developing telencephalon (3). The loss of FOXG1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (2,4).
Background References:
  • Murphy DB, Wiese S, Burfeind P, et al. Human brain factor 1, a new member of the fork head gene family. Genomics 1994; 21:551-7.
  • Kumamoto T, Toma K, Gunadi, et al. Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression. Cell Rep. 2013; 3:931-45.
  • Miyoshi G and Fishell G. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron 2012;74:1045-58.
  • Mencarelli MA, Spanhol-Rosseto A, Artuso R, et al. Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. J. Med. Genet. 2010; 47:49-53.
Buffer:
FOXG1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Immunogen:
FOXG1 antibody was raised against an 18 amino acid peptide near the center of human FOXG1.

The immunogen is located within amino acids 160 - 210 of FOXG1.
NCBI Gene ID #:
2290
NCBI Official Name:
forkhead box G1
NCBI Official Symbol:
FOXG1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 54 kDa

Observed: 54 kDa
Protein Accession #:
NP_005240
Protein GI Number:
32307177
Purification:
FOXG1 antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience,Stem Cell
SPECIFICITY:
FOXG1 antibody is human, mouse and rat reactive.
Swissprot #:
P55316
User NOte:
Optimal dilutions for each application to be determined by the researcher.