MALT1 Antibody
| Code | Size | Price |
|---|
| PSI-8097-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8097-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
MALT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1
Application Note:
MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).
Background References:
- Dielamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93:3601-9.
- Lin X and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 2004; 16:429-35.
- Rosebeck S, Rehman AO, Lucas PC, et al. From MALT lymphoma to the CBM signalsome: three decades of discovery. Cell Cycle 2011; 10:2485-96.
- Staal J, Bekaert T, and Beyaert R. Regulation of NF-kB signaling by caspases and MALT1 paracaspase. Cell Res. 21:40-54.
Buffer:
MALT1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.
The immunogen is located within amino acids 630 - 680 of MALT1.
The immunogen is located within amino acids 630 - 680 of MALT1.
NCBI Gene ID #:
10892
NCBI Official Name:
mucosa associated lymphoid tissue lymphoma translocation gene 1
NCBI Official Symbol:
MALT1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 91 kDa
Observed: 96 kDa
Observed: 96 kDa
Protein Accession #:
NP_006776
Protein GI Number:
5803078
Purification:
MALT1 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Immunology
SPECIFICITY:
MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.
Swissprot #:
Q9UDY8
User NOte:
Optimal dilutions for each application to be determined by the researcher.