Amyloid-Beta 3 Antibody

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ProSci
Product Code: PSI-39-850
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-39-850-0.05mg0.05mg£782.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Human
  • Non-Human Primates
  • Sheep
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Documents

Further Information

Additional Names:
Amyloid-Beta 3-pyr E, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4
Application Note:
ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing)
Background:
Pyro-glutamic acid truncated amyloid beta 3-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyro E modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β. Pyro-glutamic acid truncated amyloid beta 3-40/42?s exact involvement in the pathophysiology of Alzheimer?s disease has not been established.
Background References:
  • Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9
  • He W, Barrow CJ. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry. 1999 Aug 17;38(33):10871-7
  • Alzheimer research forum review see http://www.alzforum.org/new/detailprint.aspid=1577
  • Youssef I, Florent-B?chard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier JL, Leininger-Muller B, Kriem B, Oster T, Pillot T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. Neurobiology of Aging 29 (2008) 1319-1333
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
A synthetic peptide corresponding to the N-terminus 3-pyro E start point.
NCBI Gene ID #:
351
NCBI Official Name:
amyloid beta (A4) precursor protein
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P05067
Protein GI Number:
112927
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
P05067
User NOte:
Optimal dilutions for each application to be determined by the researcher.