Huntington Protein Antibody
| Code | Size | Price |
|---|
| PSI-39-864-0.1mg | 0.1mg | £782.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
HD, IT15, HD
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Background:
Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington?s disease protein is ~350 kDa in size and is localized in the brain.
Background References:
- Huntington's disease: from pathology and genetics to potential therapies. Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Biochem J. 2008 Jun 1;412(2):191-209
- Huntington disease models and human neuropathology: similarities and differences. Vonsattel JP. Acta Neuropathol. 2008 Jan;115(1):55-69
- CHD proteins: a diverse family with strong ties. Hall JA, Georgel PT. Biochem Cell Biol. 2007 Aug;85(4):463-76
- Characterization and localization of the Huntington disease gene product. Andr? T. Hoogeveen*, Rob Willemsen, Nicolle Meyer, Karien E.de Roolj1, Raymund A.C. Roos2, Gert-Jan B.van Ommen1 and Hans Galjaard, Hum Mol Genet. 1993 Dec;2(12):2069-73
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
A synthetic peptide corresponding to the N-terminus.
NCBI Gene ID #:
3064
NCBI Official Name:
huntingtin
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAB38240
Protein GI Number:
296434520
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
P42858
User NOte:
Optimal dilutions for each application to be determined by the researcher.