PARL Antibody
| Code | Size | Price |
|---|
| PSI-39-872-0.1mg | 0.1mg | £782.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Chicken (Gallus)
- Human
- Mouse
- Non-Human Primates
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Presenilin associated, rhomboid-like protein , PSARL, PSARL1, RHBDS1, PRO2207, PSENIP2
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Background:
PARL is a rhomboid protease which has been shown to be involved in mitochondrial remodeling. PARL has also been shown to have antiapoptotic activity and protects cells from mitochondrial-dependent apoptotic pathway.
Background References:
- Jeyaraju DV, Xu L, Letellier MC, Bandaru S, Zunino R, Berg EA, McBride HM, Pellegrini L., Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology., Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18562-7.
- Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling., Cell. 2006 Jul 14;126(1):27-9.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide to the C-terminus.
NCBI Gene ID #:
55486
NCBI Official Name:
presenilin associated, rhomboid-like
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001032728
Protein GI Number:
143811433
Purification:
Affinity Purified
Research Area:
Neuroscience,Apoptosis
Swissprot #:
Q9H300
User NOte:
Optimal dilutions for each application to be determined by the researcher.