HGF Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-184-0.002mg | 0.002mg | £300.00 |
Quantity:
| PSI-40-184-0.01mg | 0.01mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized HGF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted HGF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing
Documents
Further Information
Additional Names:
SF, HGFB, HPTA, F-TCF, DFNB39, Hepatocyte growth factor, Hepatopoietin-A, SF
Background:
HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells. The expected ED50 for this effect is 1.0-20.0 ng/ml.
NCBI Gene ID #:
3082
NCBI Official Name:
hepatocyte growth factor (hepapoietin A; scatter factor)
NCBI Official Symbol:
HGF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000592.3
Protein GI Number:
33859835
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
(BTI-Tn-5B1-4) High-5 Insect cells
Swissprot #:
P14210