ANG-2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-540-0.005mg | 0.005mg | £300.00 |
Quantity:
| PSI-40-540-0.02mg | 0.02mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
The lyophilized ANG-2 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted ANG-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
Documents
Further Information
Additional Names:
ANG2, AGPT2, Angiopoietin-2, ANG-2
Background:
ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha helix rich "coiled coil? N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 - 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.
Biological Activity:
Biological activity was determined by its ability to stimulate tubulogenesis in HUVEC cells using a concentration of 0.2 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
285
NCBI Official Name:
angiopoietin 2
NCBI Official Symbol:
ANGPT2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001112359.1
Protein GI Number:
169646749
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
O15123